![]() ![]() Configuration mistakes in Outlook settings are the most common reason, but this happens only when there's a recent or new configuration of an email account.Error 421"Ĭommon reasons for this critical Outlook error 421 are: "An unknown error has occurred: Server error 421"."server responded 421 cannot connect to SMTP server".SMTP error 421 may display in formats like: It may also occur once you have crossed a restricted limit on the email account. This error occurs for temporary problems while sending and receiving emails on the server. ![]() The error is to be resolved on time or may cause great inconvenience as it stops and locks all the activities related to your email account. Outlook Error 421 is a common critical SMTP error that hampers transmissions of emails. Part 2: How To Fix "421 Cannot Connect To SMTP Server in Outlook" Issue?.
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